Table of Contents Table of Contents 2 List of Tables 4 List of Figures 4 Introduction 5 Global Markets Direct Report Coverage 5 Corneal Graft Rejection Overview 6 Therapeutics Development 7 Pipeline Products for Corneal Graft Rejection - Overview 7 Corneal Graft Rejection - Therapeutics under Development by Companies 8 Corneal Graft Rejection - Pipeline Products Glance 9 Late Stage Products 9 Early Stage Products 10 Corneal Graft Rejection - Products under Development by Companies 10 Corneal Graft Rejection - Companies Involved in Therapeutics Development 11 Circadian Technologies Limited 11 Gene Signal International SA 12 Oxford BioMedica Plc 13 Santen Pharmaceutical Co., Ltd. 14 Corneal Graft Rejection - Therapeutics Assessment 15 Assessment by Monotherapy Products 15 Assessment by Target 16 Assessment by Mechanism of Action 18 Assessment by Route of Administration 20 Assessment by Molecule Type 22 Drug Profiles 24 aganirsen - Drug Profile 24 Product Description 24 Mechanism of Action 24 R&D Progress 24 cyclosporine - Drug Profile 26 Product Description 26 Mechanism of Action 26 R&D Progress 26 Cyndacel-M - Drug Profile 29 Product Description 29 Mechanism of Action 29 R&D Progress 29 GB-301 - Drug Profile 31 Product Description 31 Mechanism of Action 31 R&D Progress 31 OXB-202 - Drug Profile 32 Product Description 32 Mechanism of Action 32 R&D Progress 32 Stromal Cell Therapy for Corneal Graft Rejection - Drug Profile 33 Product Description 33 Mechanism of Action 33 R&D Progress 33 VGX-100 - Drug Profile 34 Product Description 34 Mechanism of Action 34 R&D Progress 34 Corneal Graft Rejection - Recent Pipeline Updates 37 Corneal Graft Rejection - Dormant Projects 41 Corneal Graft Rejection - Product Development Milestones 42 Featured News & Press Releases 42 Jan 30, 2012: VGX-100 Identified As Potential New Therapy For Improving Corneal Graft Survival 42 Appendix 43 Methodology 43 Coverage 43 Secondary Research 43 Primary Research 43 Expert Panel Validation 43 Contact Us 43 Disclaimer 44

List of Tables Number of Products under Development for Corneal Graft Rejection, H1 2016 7 Number of Products under Development by Companies, H1 2016 8 Comparative Analysis by Late Stage Development, H1 2016 9 Products under Development by Companies, H1 2016 10 Corneal Graft Rejection - Pipeline by Circadian Technologies Limited, H1 2016 11 Corneal Graft Rejection - Pipeline by Gene Signal International SA, H1 2016 12 Corneal Graft Rejection - Pipeline by Oxford BioMedica Plc, H1 2016 13 Corneal Graft Rejection - Pipeline by Santen Pharmaceutical Co., Ltd., H1 2016 14 Assessment by Monotherapy Products, H1 2016 15 Number of Products by Stage and Target, H1 2016 17 Number of Products by Stage and Mechanism of Action, H1 2016 19 Number of Products by Stage and Route of Administration, H1 2016 21 Number of Products by Stage and Molecule Type, H1 2016 23 Corneal Graft Rejection Therapeutics - Recent Pipeline Updates, H1 2016 37 Corneal Graft Rejection - Dormant Projects, H1 2016 41 List of Figures Number of Products under Development for Corneal Graft Rejection, H1 2016 7 Number of Products under Development by Companies, H1 2016 8 Assessment by Monotherapy Products, H1 2016 15 Number of Products by Targets, H1 2016 16 Number of Products by Stage and Targets, H1 2016 16 Number of Products by Mechanism of Actions, H1 2016 18 Number of Products by Stage and Mechanism of Actions, H1 2016 18 Number of Products by Routes of Administration, H1 2016 20 Number of Products by Stage and Routes of Administration, H1 2016 20 Number of Products by Molecule Types, H1 2016 22 Number of Products by Stage and Molecule Types, H1 2016 22

Circadian Technologies Limited Gene Signal International SA Oxford BioMedica Plc Santen Pharmaceutical Co., Ltd.